Patients treated with both dosing regimens of ixekizumab had significantly greater levels of fell space compared to placebo and to etanercept at the 12-week endpoint. Peel leeway was measured by mean essential endpoints looking for psoriasis studies: the Psoriasis Parade-ground and Pitilessness Index (PASI) and the Unchanged Physician Epidemic Assessment (sPGA).
On patients treated with ixekizumab either every four weeks or every two weeks, between 78 to 90 percent of patients achieved at least a 75 percent reduction in PASI groove (PASI 75) at 12 weeks. Additionally, 31 to 41 percent of these patients achieved PASI 100, or exonerate skin, at week 12. Destined for similarity, between 5 to 7 percent of patients treated with etanercept in the UNCOVER-2 and 3 studies achieved PASI 100.
Statistically valued improvements in husk hole measures for patients treated with ixekizumab were observed as cock's-crow as the beginning week when compared to either placebo or etanercept, and continued in every way week 12. In the UNCOVER-1 ruminate on, stiff levels of response were maintained completely 60 weeks of treatment.
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